William Brothers

Post-Doctoral Fellow

Cellular and Molecular Medicine

 

 

Summary

Will received his B.Sc. in Biology from the University of British Columbia while also working as a laboratory technician at the BC Cancer Research Centre under the supervision of Dr. Marco Marra. He then went on to do his Ph.D. at McGill University in Dr. Marc Fabian’s lab, focusing on how cytoplasmic ribonucleoprotein granules regulate mRNA decay pathways. Will’s research interests centre around understanding whether RNA granules are functionally and therapeutically relevant targets in the contexts of human neurobiology and neurodegenerative disease.

In a former life, Will represented Canada at the World Championships in swimming and he is still very passionate about sports and human performance. So outside of the lab you can probably find him training for triathlons either in the pool, on his bike, or running.

 

Education

B.Sc., Biology, The University of British Columbia, 2018

Ph.D., Experimental Medicine, McGill University, 2023

 

Contact

wbrothers@health.ucsd.edu

Twitter: @will_brothers

Publications

  • Brothers W. R., Ali F., Kajjo S., Fabian M. R. (2023). The EDC4-XRN1 axis controls P-body dynamics to couple mRNA decapping with decay. EMBO J e113933.

  • Takemon Y., LeBlanc V. G., Song J., Chan S. Y., Lee S. D., Trinh D. L., Ahmad S. T., Brothers W. R., … , & Marra M. A. (2023). Multi-Omic Analysis of CIC’s Functional Networks Reveals Novel Interaction Partners and a Potential Role in Mitotic Fidelity. Cancers, 15(10), 2805.

  • Brothers W. R., Fakim H., Kajjo S., & Fabian M. R. (2022). P-bodies directly regulate MARF1-mediated mRNA decay in human cells. Nucleic Acids Research, 50(13), 7623-7636.

  • Kajjo S., Sharma S., Chen S., Brothers W. R., Cott M., Hasaj B., Jovanovic P., Larsson O., & Fabian M. R. (2022). PABP prevents the untimely decay of select mRNA populations in human cells. EMBO J e108650.

  • Brothers W. R., Hebert S., Kleinman C., & Fabian M. R. (2020). A non-canonical role for the EDC4 decapping factor in regulating MARF1-mediated mRNA decay. eLife 9:e54995.