Summer Fair

M.D./Ph.D Student

Biomedical Sciences Program and Medical Scientist Training Program

 

 

Summary

Summer is a physician scientist (MD/PhD) trainee who is broadly interested in developmental neurobiology and stem cell technologies.

She began her research career as an undergraduate at The Ohio State University, where she studied autonomic nervous system development and dysautonomia under the mentorship of Jose Otero, MD, PhD.

After completing her undergraduate education, she received an NIH trainee award to pursue a unique post-baccalaureate experience at Lurie Children’s Hospital in Chicago, IL under the mentorship of Aaron Hamvas, MD. There, her work aimed to improve the care for medically complex patients with autonomic nervous system disorders, including preterm infants.

Summer then went on to work with Mark Hester, PhD at Nationwide Children’s Hospital, where she investigated the pathogenesis of various neurodevelopmental diseases with human cerebral organoids and other in-vitro models.Now, as a member of the Yeo Lab, Summer hopes to advance our mechanistic understanding of RBP function in normal and diseased human brain development.

Outside of the lab, Summer enjoys rewatching ‘90s sitcoms, trying new plant-based recipes, practicing reformer pilates, and convincing herself she can DIY any home renovation project.

 

Education

B.S., Neuroscience, The Ohio State University 2017

 

Contact

sfair@health.ucsd.edu

Publications

  • Fair S. R., Schwind W., Julian D., Biel A., Guo G., Rutherford R., Ramadesikan S., Westfall J., Miller K. E., Kararoudi M. N., Hickey S. E., Mosher T. M., McBride K. L., Neinast R., Fitch J., Lee D., White P., Wilson R. K., Bedrosian T. A., Koboldt D. C., Hester M. E. Cerebral organoids containing an AUTS2 missense variant model microcephaly. Brain. 2022 Jul 8:awac244. doi: 10.1093/brain/awac244.

  • Batzios S., Tal G., DiStasio A. T., Peng Y., Charalambous C., Nicolaides P., Kamsteeg E. J., Korman S. H., Mandel H., Steinbach P. J., Yi L., Fair S. R., Hester M. E., Drousiotou A., Kaler S. G. Newly identified disorder of copper metabolism caused by variants in CTR1, a high-affinity copper transporter. Hum Mol Genet. 2022 Aug 1:ddac156. doi: 10.1093/hmg/ddac156.

  • Biel A., Castanza A. S., Rutherford R., Fair S. R., Chifamba L., Wester J. C., Hester M. E., Hevner R. F. AUTS2 Syndrome: Molecular Mechanisms and Model Systems. Front Mol Neurosci. 2022 Mar 31;15:858582. doi: 10.3389/fnmol.2022.858582.

  • Venkataraman L., Fair S. R., McElroy C. A., Hester M. E., Fu H. Modeling neurodegenerative diseases with cerebral organoids and other three-dimensional culture systems: focus on Alzheimer’s disease. Stem Cell Rev Rep. 2021 Feb;18(2):696-717. doi: 10.1007/s12015-020-10068-9.

  • Koboldt D. C., Miller K. E., Miller A. R., Bush J. M., McGrath S., Leraas K., Crist E., Fair S. R., Schwind W., Wijeratne S., Fitch J., Leonard J., Shaikhouni A., Hester M. E., Magrini V., Ho M. L., Pierson C. R., Wilson R. K., Ostendorf A. P., Mardis E. R., Bedrosian T. A. PTEN somatic mutations contribute to spectrum of cerebral overgrowth. Brain. 2021 Nov 29;144(10):2971-2978. doi: 10.1093/brain/awab173.

  • Watanabe F., Schoeffler A., Fair S. R., Hester M. E., Fedorko J., Imitola J. Generation of Neurosphere-Derived Organoid-Like- Aggregates (NEDAS) from Neural Stem Cells. Curr Protoc. 2021 Feb;1(2):e15. doi: 1s0.1002/cpz1.15.

  • Fair S. R., Julian D., Hartlaub A. M., Pusuluri S. T., Malik G., Summerfied T. L., Zhao G., Hester A. B., Ackerman W. E. 4th, Hollingsworth E. W., Ali M., McElroy C. A., Buhimschi I. A., Imitola J., Maitre N. L., Bedrosian T. A., Hester M. E. Electrophysiological Maturation of Cerebral Organoids Correlates with Dynamic Morphological and Cellular Development. Stem Cell Reports. 2020 Oct 13;15(4):855-868. doi: 10.1016/j.stemcr.2020.08.017.

  • Czeisler C. M., Silva T. M., Fair S. R., Liu J., Tupal S., Kaya B., Cowgill A., Mahajan S., Silva P. E., Wang Y., Blissett A. R., Göksel M., Borniger J. C., Zhang N., Fernandes-Junior S. A., Catacutan F., Alves M. J., Nelson R. J., Sundaresean V., Rekling J., Takakura A. C., Moreira T. S., Otero J. J. The role of PHOX2B-derived astrocytes in chemosensory control of breathing and sleep homeostasis. J Physiol. 2019 Apr;597(8):2225-2251. doi: 10.1113/JP277082.

  • Fair S. R. (2019). Issue Cover Page. J Physiol, 597: 2115-2116. doi:10.1113/tjp.13083. Generated and captured images of data that appear on the J Physiol cover.

  • Alves M. J., Goksel M., Kaya B., Mostafa H., Gygli P., Stephens J., Fair S. R., Otero J. J., Czeisler C. M. CCNA2 Ablation in Aged Mice Results in Abnormal rRNA Granule Accumulation in Hippocampus. Am J Pathol. 2019 Feb;189(2):426-439. doi: 10.1016/j.ajpath.2018.10.020. (edited) 

  • Mei-Ling Liu J., Fair S. R., Kaya B., Zuniga J. N., Mostafa H. R., Alves M. J., Stephens J. A., Jones M., Aslan M. T., Czeisler C., Otero J. J. Development of a Novel FIJI-Based Method to Investigate Neuronal Circuitry in Neonatal Mice. Dev Neurobiol. 2018 Nov;78(11):1146-1167. doi: 10.1002/dneu.22636.