Sam Landry
Graduate Student (Ph.D.)
Biological Sciences
Summary
Sam received his B.Sc. in Chemical Engineering from the University of Maine, where he also worked in biomaterials and developmental biology laboratories. He then joined the Human Embryonic Stem Cell Core at Boston Children’s Hospital under the mentorship of George Daley and Thorsten Schlaeger, focusing on hiPSC-derived red blood cell therapies and CRISPR-based gene editing.
Following this, Sam worked at Sana Biotechnology, where he contributed to the development of allogeneic CAR-T cell therapies and in vivo CAR-T gene delivery platforms. His research interests were shaped by his experience in cell and gene therapy, particularly the tension between their transformative therapeutic potential and the challenges of scalability and cost.
Motivated by these limitations, Sam now focuses on developing technologies to screen and engineer more efficient mRNA-based therapeutics, with the goal of making next-generation medicines more accessible and economically viable.
Education
B.S. Chemical Engineering, Biomaterials, and Nanotechnology, University of Maine, 2017
Publications
X. Hu, M. Dao, K. White, C. Gattis, R. Clarke, S. Landry, R. Basco, E. Tham, A. Tucker, E. Luo, C.
Bandoro, E. Chu, C. Young, A. E. Foster, W. E. Dowdle, E. J. Rebar, T. J. Fry, S. Schrepfer; Engineered
Hypoimmune Allogeneic CAR T Cells Exhibit Innate and Adaptive Immune Evasion Even after
Sensitization in Humanized Mice and Retain Potent Anti-Tumor Activity. Blood 2021; 138
(Supplement 1): 1690.
Chen, M. J., Rocha, E. L., Cahan, P., Kubaczka, C., Hunter, P., Sousa, P., Mullin, N. K. , Yuko, F.,
Nguyen, M., Tan, Y., Landry, S., Han, A., Yang, S., Lu, Y., Jha, K. D., Vo, L.. T., Zhou, Y., North, T. E., Zon
L I., Daley G. Q., Schlaeger, T. M. Transcriptome Dynamics of Hematopoietic Stem Cell Formation
Revealed Using a Combinatorial Runx1 and Ly6a Reporter System. Stem Cell Reports (2020), 14(5),
956-971. doi:10.1016/j.stemcr.2020.03.020
Dadoo, N., Landry, S. B., Bomar, J. D., & Gramlich, W. M. Synthesis and Spatiotemporal Modification
of Biocompatible and Stimuli-Responsive Carboxymethyl Cellulose Hydrogels Using Thiol-
Norbornene Chemistry. Macromolecular Bioscience (2017), 17(9), 1700107.
doi:10.1002/mabi.201700107