Grant Funding

Current Grant Funding

Federal

• NIH R01 HG004659 (NHGRI): Functional RNA elements in the human genome

• NIH R01 HG011864 (NHGRI): STAMP technology to enable single-cell and isoform-sensitive detection of RBP sites

• NIH RF1 MH126719 (NHGRI): Ribo-STAMPEDE: novel tools for molecular profiling of brain cell types — with Giordano Lippi at TSRI

• NIH U24 HG009889 (NHGRI): A comprehensive binding and functional map of human RNA-binding proteins — with Brent Graveley at UConn

• NIH U24 HG011735 (NHGRI via the Jackson Laboratory’s TDCC / PI Mark Adams): Recruitable and inducible tools to map protein-RNA interactions at scale — with Rahul Kohli at UPenn

• NIH R01 HD101534 (NICHD): Dissecting the role of FMRP in RNA processing using human stem cell models — with Lindy Barrett (PI) at the Broad Institute

• NIH R01 DK018477 (NIDDK): Enhancer connectomes in regulation of gene expression — with Geoff Rosenfeld (PI) at UCSD

• NIH R01 NS103172 (NINDS): Therapeutic strategies for microsatellite expansion diseases using RNA-targeting — with Maury Swanson at U.Florida

• NIH R01 MH131907 (NIMH): Human Isogenic Organoid Models of Genetic Forms of Autism to Identify Convergent and Divergent Pathomechanisms in Autism — with Stefan Aigner in the Yeo lab

• NIH R01 CA259562 (NCI): Dissecting stress granule dependencies in leukemia stem cells — with Kristin Hope at Princess Margaret Cancer Centre / University of Toronto

• CDC contract: Total microbial knowledge of wastewater on a college campus: lessons for NWSS — with Rob Knight and Louise Laurent at UCSD (PI), and Kristian Andersen at TSRI

• CDC contract: Genomic sequencing of SARS-CoV-2 to investigate local and cross-border emergence and spread — with Kristian Andersen (PI) at TSRI, and Rob Knight (PI) and Louise Laurent at UCSD

Non-federal

• Chan Zuckerberg Initiative grant: The Diversity and Science Lecture (DASL) Series and Platform

• Chan Zuckerberg Initiative grant: Enhancing ASO Efficacy through Machine Learning of RNA Accessibility

• Chan Zuckerberg Initiative grant: Innovative Approaches for Charting State-Dependent RNA Metabolic Networks — with Nigel Goldenfeld at UCSD, Christian Metallo at Salk, and Chris Parker at TSRI

• California Institute for Regenerative Medicine DISC2-13102 grant: RNA-directed therapy for Huntington's disease

• Target ALS Foundation Industry-Led Consortium grant: RNA granules as novel therapeutic targets in ALS/FTD — with Joe Lewcock at Denali Therapeutics, and Eric Bennett and John Ravits at UCSD

• Roche ROADS Innovation grant: Modulation of RNA subcellular localization for the treatment or neurological diseases

• Ionis Ion-ARPA Initiative grant: “Mirror” cloaking of therapeutic payloads — with Neal Devaraj (PI) at UCSD, Danielle Tullman-Ercek at Northwestern, and Luc Teyton at TSRI

Previous Grant Funding

Federal

• DoD W81XWH-21-1-0323: RNA-directed therapy for C9ORF72-linked ALS using engineered zinc finger nucleases — with Martin Marsala at UCSD [2021-2023]

• NIH P01 AI132122 (NIAID): Molecular determinants of tissue-resident memory T cell Fate in acute and chronic infection — with Ananda Goldrath (contact PI), Elena Zuniga, John Chang, and Wei Wang at UCSD [2018-2023]

• NIH U01 MH115747 (NIMH): The Psychiatric Cell Map Initiative (PCMI) — with Nevan Krogan (PI) at UCSF [2020-2022]

• NIH R01 NIH HD085902 (NICHD): Reconstruction of cardiovascular regulatory networks from large-scale single-cell analyses of cardiovascular lineages — with Neil Chi at UCSD [2016-2021]

• NIH U01 HG009417 (NHGRI): Analysis of functional genetic variants in RNA processing and expression — with Grace Xiao (PI), UCLA [2017-2022]

• U41 NIH HG009889 (NHGRI): A comprehensive functional map of human protein-RNA interactions — with Brent Graveley at UConn [2018-2022]

• NIH R01 EY029166 (NEI): Application of RNA-targeting Cas9 to Fuchs' dystrophy — with Natalie Afshari at UCSD and the Shiley Eye Institute [2018-2022]

• NIH R01 HL137223 (NHLBI): Analysis of RNA binding proteins directing hematopoietic stem cell fate — with Kristin Hope, Princess Margaret Cancer Centre, Toronto (Canada) [2018-2022]

• IARPA grant: High throughput, sensitive, rapid detection of viral infection and spread with an innovative isothermal lateral flow assay — with Yu-Hwa Lo (PI) at UCSD [2020-2021]

• DoD W81XWH19-1-0181: RNA-directed therapy for C9ORF72-linked ALS — with Martin Marsala at UCSD [2019-2021]

• NIH R01 AI123202 (NIAID): Using single-cell RNA-seq to interrogate host immunity to pathogens — with with John Chang at UCSD [2016-2021]

• NIH R56 AG069098 (NIA): Evaluating and Targeting RNA granules in neurodegenerative diseases — with Eric Bennett, UCSD [2020-2021]

• NIH U19 MH107367 (NIMH): Collaboration on preclinical autism cellular assays, biosignatures, and network analyses (Copacabana) — with Alysson Muotri, Larry Goldstein, and Shelley Halpain at UCSD, and Ed Callaway at the Salk Institute [2015-2021]

• NIH R01 HD085902 (NICHD): Reconstruction of cardiovascular regulatory networks from large-scale single-cell analyses of cardiovascular lineages — with Neil Chi at UCSD [2016-2021]

• NIH R01 HL137219 (NHLBI): Dissecting splicing factor mutations in iPSCs — with Eirini Papapetrou at Icahn [2017-2021]

• NIH R56 AG055824 (NIA): The Role of alternative splicing in neurodegeneration — with Towfique Raj (PI) at Mt. Sinai [2019-2020]

• NIH U54 HG007005 (NHGRI): Comprehensive analysis of functional RNA elements encoded in the human genome — with Brent Graveley at UConn [2012-2019]

• NIH R01 NS075449 (NGHRI): Defining the messenger RNP code in the brain [2012-2017]

• NIH R01AI095277 (NIAID): Regulation and function of polarity and asymmetric cell division in immunity — with John Chang (PI) at UCSD [2014-2016]

• NIH U01 HL107442 (NHLBI): Regulatory genomic studies in a cohort of IPS cell derived cardiomyocytes — with Kelly Frazer (PI) at UCSD [2014-2015]

• NIH R01 GM084317 (NIGMS): Genomic measurement of alternative splicing — with Manny Ares (PI) at UCSC [2009-2012]

Non-federal

• Paul G. Allen Family Foundation grant: Early manifestations of subcellular defects in neurodegenerative diseases (Paul G. Allen Distinguished Investigatorship) [2020-2023]

• CHDI Foundation grant: Identification of HTT interaction partners [2021-2023]

• Chan Zuckerberg Initiative Neurodegeneration Challenge Network grant: Investigation of nuclear pore complex alterations in ALS/FTD — with Jeff Rothstein at Johns Hopkins [2019-2022]

• Chan Zuckerberg Initiative Neurodegeneration Challenge Network grant: Subcellular RNA dynamics in HD — with Leslie Thompson (PI) at UCI [2021-2022]

• Takeda Millenium Pharamceuticals grant: Targeting RNA binding proteins in fragile X syndrome: small molecule inhibitors of UBAP2L [2020-2022]

• Chan Zuckerberg Initiative Collaborative Pilot Project grant: Deciphering the microglial inflammatory response in 3D — with Nicole Coufal and Chris Glass at UCSD [2020-2022]

• Simons Foundation SFARI Pilot Award: Inhibition of UBAP2L as a treatment of fragile X syndrome [2020-2022]

• Larry L. Hillblom Foundation grant: Stress granule components as potential modulators of protein aggregation in ALS — with Eric Bennett at UCSD [2019]

• ALS Association grant: Discovery of stress granule components in models of ALS [2016-2019]

• Takeda-Sanford Alliance grant: Integration of single cell RNA-sequencing and bacTRAP technology to identify and profile novel cell types in the gastrointestinal tract [2016-2018]

• ALS Association grant: Comprehensive analysis of RNA localization and transport mechanisms in wildtype and ALS motor neurons [2016-2018]

• California Institute for Regenerative Medicine Basic Biology IV grant: Stem cell models to analyze the role of mutated C9ORF72 in neurodegeneration [2013-2016]

• California Institute for Regenerative Medicine Early Translation III grant: Molecules to correct aberrant RNA signature in human diseased neurons [2012-2015]

• Brain Research Foundation grant: Global analysis of transcriptome diversity at the single cell level in human neurons [2014-2015]

• California Institute for Regenerative Medicine Basic Biology III grant: Neural and general splicing factors control self-renewal, neural survival and differentiation [2011-2014]

• California Institute for Regenerative Medicine Basic Biology III grant: Viral-host interactions affecting neural differentiation of human progenitors — with Debbie Spector at UCSD [2011-2014]

• California Institute for Regenerative Medicine Tools and Technologies II grant: Developing a method for rapid identification of high-quality disease specific hIPSC lines — with Larry Goldstein at UCSD [2011-2014]

• Roche EIN grant: Reversing RNA processing defects, a common basis for neurodegenerative disorders [2012-2014]

• ALS Association grant: Identification of an RNA signature of TDP-43 dependent misregulation in human neurons [2011-2013]

• California Institute for Regenerative Medicine Basic Biology I grant: RNA binding protein-mediated post-transcriptional networks regulating hPSC pluripotency [2009-2012]