Grant Funding

Current Grant Funding

Federal

• NIH R01 HG011864 (NHGRI): STAMP technology to enable single-cell and isoform-sensitive detection of RBP sites

• NIH RF1 MH126719 (NHGRI): Ribo-STAMPEDE: novel tools for molecular profiling of brain cell types — with Giordano Lippi at TSRI

• NIH U24 HG009889 (NHGRI): A comprehensive binding and functional map of human RNA-binding proteins — with Brent Graveley at UConn

• NIH R01 HD101534 (NICHD): Dissecting the role of FMRP in RNA processing using human stem cell models — with Lindy Barrett (PI) at the Broad Institute

• NIH R01 DK018477 (NIDDK): Enhancer connectomes in regulation of gene expression — with Geoff Rosenfeld (PI) at UCSD

• NIH R01 NS103172 (NINDS): Therapeutic strategies for microsatellite expansion diseases using RNA-targeting — with Maury Swanson at U.Florida

• NIH R01 MH131907 (NIMH): Human isogenic organoid models of genetic forms of autism to identify convergent and divergent pathomechanisms in autism — with Stefan Aigner in the Yeo lab

• NIH R01 CA259562 (NCI): Dissecting stress granule dependencies in leukemia stem cells — with Kristin Hope at Princess Margaret Cancer Centre / University of Toronto

Non-federal

• Chan Zuckerberg Initiative Advancing Imaging Through Collaborative Projects grant — with Bogdan Bintu (PI) at UCSD and others

• Chan Zuckerberg Initiative grant: The Diversity and Science Lecture (DASL) Series and Platform

• Chan Zuckerberg Initiative grant: Enhancing ASO Efficacy through Machine Learning of RNA Accessibility

• Chan Zuckerberg Initiative Exploratory Cell Networks grant: Innovative Approaches for Charting State-Dependent RNA Metabolic Networks — with Nigel Goldenfeld at UCSD, Christian Metallo at Salk, and Chris Parker at TSRI

• Chan Zuckerberg Initiative Collaborative Pairs Pilot Project Award: New subcellular microenvironment-mapping tools for the CNS — with Dave Shechner at U. Washington

• Target ALS Foundation Industry-Led Consortium grant: RNA granules as novel therapeutic targets in ALS/FTD — with Joe Lewcock at Denali Therapeutics, and Eric Bennett and John Ravits at UCSD

• CIRM DISC4 (ReMIND) grant: Modeling the genetic basis of psychopathology in schizophrenia and autism — with Jonathan Sebat (PI), and co-investigators Lilia Iakoucheva, Trey Ideker, and Alysson Muotri at UCSD, Anne Bang at the Sanford Burnham Prebys, Carrie Bearden at UCLA, and Sebastien Jacquemont at U. Montreal

Previous Grant Funding

Federal

• NIH U24 HG011735 (NHGRI via the Jackson Laboratory’s TDCC / PI Mark Adams): Recruitable and inducible tools to map protein-RNA interactions at scale — with Rahul Kohli at UPenn [2023-2024]

• NIH R01 HG004659 (NHGRI): Functional RNA elements in the human genome [2008-2024]

• DoD ALS Research Program Therapeutic Idea Award: RNA-directed therapy for C9ORF72-linked ALS using engineered zinc finger nucleases — with Martin Marsala at UCSD [2021-2023]

• NIH P01 AI132122 (NIAID): Molecular determinants of tissue-resident memory T cell Fate in acute and chronic infection — with Ananda Goldrath (contact PI), Elena Zuniga, John Chang, and Wei Wang at UCSD [2018-2023]

• NIH U01 MH115747 (NIMH): The Psychiatric Cell Map Initiative (PCMI) — with Nevan Krogan (PI) at UCSF [2020-2022]

• NIH R01 NIH HD085902 (NICHD): Reconstruction of cardiovascular regulatory networks from large-scale single-cell analyses of cardiovascular lineages — with Neil Chi at UCSD [2016-2021]

• NIH U01 HG009417 (NHGRI): Analysis of functional genetic variants in RNA processing and expression — with Grace Xiao (PI), UCLA [2017-2022]

• U41 NIH HG009889 (NHGRI): A comprehensive functional map of human protein-RNA interactions — with Brent Graveley at UConn [2018-2022]

• NIH R01 EY029166 (NEI): Application of RNA-targeting Cas9 to Fuchs' dystrophy — with Natalie Afshari at UCSD and the Shiley Eye Institute [2018-2022]

• NIH R01 HL137223 (NHLBI): Analysis of RNA binding proteins directing hematopoietic stem cell fate — with Kristin Hope, Princess Margaret Cancer Centre, Toronto (Canada) [2018-2022]

• IARPA grant: High throughput, sensitive, rapid detection of viral infection and spread with an innovative isothermal lateral flow assay — with Yu-Hwa Lo (PI) at UCSD [2020-2021]

• DoD ALS Research Program Therapeutic Idea Award: RNA-directed therapy for C9ORF72-linked ALS — with Martin Marsala and Don Cleveland at UCSD [2019-2021]

• NIH R01 AI123202 (NIAID): Using single-cell RNA-seq to interrogate host immunity to pathogens — with with John Chang at UCSD [2016-2021]

• NIH R56 AG069098 (NIA): Evaluating and Targeting RNA granules in neurodegenerative diseases — with Eric Bennett, UCSD [2020-2021]

• NIH U19 MH107367 (NIMH): Collaboration on preclinical autism cellular assays, biosignatures, and network analyses (Copacabana) — with Alysson Muotri, Larry Goldstein, and Shelley Halpain at UCSD, and Ed Callaway at the Salk Institute [2015-2021]

• NIH R01 HD085902 (NICHD): Reconstruction of cardiovascular regulatory networks from large-scale single-cell analyses of cardiovascular lineages — with Neil Chi at UCSD [2016-2021]

• NIH R01 HL137219 (NHLBI): Dissecting splicing factor mutations in iPSCs — with Eirini Papapetrou at Icahn [2017-2021]

• NIH R56 AG055824 (NIA): The Role of alternative splicing in neurodegeneration — with Towfique Raj (PI) at Mt. Sinai [2019-2020]

• NIH U54 HG007005 (NHGRI): Comprehensive analysis of functional RNA elements encoded in the human genome — with Brent Graveley at UConn [2012-2019]

• NIH R01 NS075449 (NGHRI): Defining the messenger RNP code in the brain [2012-2017]

• NIH R01AI095277 (NIAID): Regulation and function of polarity and asymmetric cell division in immunity — with John Chang (PI) at UCSD [2014-2016]

• NIH U01 HL107442 (NHLBI): Regulatory genomic studies in a cohort of IPS cell derived cardiomyocytes — with Kelly Frazer (PI) at UCSD [2014-2015]

• NIH R01 GM084317 (NIGMS): Genomic measurement of alternative splicing — with Manny Ares (PI) at UCSC [2009-2012]

Non-federal

• Roche ROADS Innovation grant: Modulation of RNA subcellular localization for the treatment or neurological diseases [2021-2024]

• CDC contract: Total microbial knowledge of wastewater on a college campus: lessons for NWSS — with Rob Knight (PI) at UCSD and others [2022-2024]

• CDC contract: Genomic sequencing of SARS-CoV-2 to investigate local and cross-border emergence and spread — with Kristian Andersen (PI) at TSRI and others [2020-2024]

• California Institute for Regenerative Medicine DISC2-13102 grant: RNA-directed therapy for Huntington's disease [2022-2024]

• Ionis Ion-ARPA Initiative grant: “Mirror” cloaking of therapeutic payloads — with Neal Devaraj (PI) at UCSD, Danielle Tullman-Ercek at Northwestern, and Luc Teyton at TSRI [2022-2023]

• Paul G. Allen Family Foundation grant: Early manifestations of subcellular defects in neurodegenerative diseases (Paul G. Allen Distinguished Investigatorship) [2020-2023]

• CHDI Foundation grant: Identification of HTT interaction partners [2021-2023]

• Chan Zuckerberg Initiative Neurodegeneration Challenge Network grant: Investigation of nuclear pore complex alterations in ALS/FTD — with Jeff Rothstein at Johns Hopkins [2019-2022]

• Chan Zuckerberg Initiative Neurodegeneration Challenge Network grant: Subcellular RNA dynamics in HD — with Leslie Thompson (PI) at UCI [2021-2022]

• Takeda Millenium Pharamceuticals grant: Targeting RNA binding proteins in fragile X syndrome: small molecule inhibitors of UBAP2L [2020-2022]

• Chan Zuckerberg Initiative Collaborative Pilot Project grant: Deciphering the microglial inflammatory response in 3D — with Nicole Coufal and Chris Glass at UCSD [2020-2022]

• Simons Foundation SFARI Pilot Award: Inhibition of UBAP2L as a treatment of fragile X syndrome [2020-2022]

• Larry L. Hillblom Foundation grant: Stress granule components as potential modulators of protein aggregation in ALS — with Eric Bennett at UCSD [2019]

• ALS Association grant: Discovery of stress granule components in models of ALS [2016-2019]

• Takeda-Sanford Alliance grant: Integration of single cell RNA-sequencing and bacTRAP technology to identify and profile novel cell types in the gastrointestinal tract [2016-2018]

• ALS Association grant: Comprehensive analysis of RNA localization and transport mechanisms in wildtype and ALS motor neurons [2016-2018]

• California Institute for Regenerative Medicine Basic Biology IV grant: Stem cell models to analyze the role of mutated C9ORF72 in neurodegeneration [2013-2016]

• California Institute for Regenerative Medicine Early Translation III grant: Molecules to correct aberrant RNA signature in human diseased neurons [2012-2015]

• Brain Research Foundation grant: Global analysis of transcriptome diversity at the single cell level in human neurons [2014-2015]

• California Institute for Regenerative Medicine Basic Biology III grant: Neural and general splicing factors control self-renewal, neural survival and differentiation [2011-2014]

• California Institute for Regenerative Medicine Basic Biology III grant: Viral-host interactions affecting neural differentiation of human progenitors — with Debbie Spector at UCSD [2011-2014]

• California Institute for Regenerative Medicine Tools and Technologies II grant: Developing a method for rapid identification of high-quality disease specific hIPSC lines — with Larry Goldstein at UCSD [2011-2014]

• Roche EIN grant: Reversing RNA processing defects, a common basis for neurodegenerative disorders [2012-2014]

• ALS Association grant: Identification of an RNA signature of TDP-43 dependent misregulation in human neurons [2011-2013]

• California Institute for Regenerative Medicine Basic Biology I grant: RNA binding protein-mediated post-transcriptional networks regulating hPSC pluripotency [2009-2012]