Dr. Dominic Lee

Project Scientist

 

 

Summary

Dominic Lee received this PhD in at the National University of Singapore where under Prof Roger Foo at the Genome Institute of Singapore, he studied the role of chromatin architecture on gene regulation. Though cardiac specific in vivo deletion of DNA looping, his work details how cell specific DNA looping is important for enhancer-promoter interactions and insulates against aberrant ones. Prior to his, Dominic first worked as a patent executive at a law firm after he graduated from the University of Melbourne with an honours degree in Genetics. Through his time at GIS and his postdoctoral fellow at the Gene Yeo lab in Singapore and now in UCSD, Dominic is interested in the innovation and the application of novel technologies in finding solutions for urgent genetic diseases. Currently, he is working on a multi-omic solution to identifying genetic mutations on the single cell level in combining with both single cell RNA and proteomic pipelines.

 

Education

B.S., Genetics, University of Melbourne 2010

Ph.D., Medicine, National University of Singapore 2018

 

Contact

dpl005@health.ucsd.edu

Publications

  • Lee, D. P., Tan, W. L. W., Anene-Nzelu, C. G., Lee, C. J. M., Li, P. Y., Luu, T. D. A., Chan, C. X., Tiang, Z., Ng, S. L., Huang, X., Efthymios, M., Autio, M. I., Jiang, J., Fullwood, M. J., Prabhakar, S., Lieberman Aiden, E., & Foo, R. S. Y. (2019). Robust CTCF-Based Chromatin Architecture Underpins Epigenetic Changes in the Heart Failure Stress-Gene Response.

  • Hawe, J. S., Wilson, R., Schmid, K. T., Zhou, L., Lakshmanan, L. N., Lehne, B. C., Kühnel, B., Scott, W. R., Wielscher, M., Yew, Y. W., Baumbach, C., Lee, D. P., Marouli, E., Bernard, M., Pfeiffer, L., Matías-García, P. R., Autio, M. I., Bourgeois, S., Herder, C., … Chambers, J. C. (2022). Genetic variation influencing DNA methylation provides insights into molecular mechanisms regulating genomic function.

  • G. Y.-Q., D.P. Lee., Bae, H.-G., Kang, S. W., Fann, D. Y.-W., Park, J., Kim, J., Alli-Shaik, A., Lee, J., Kim, E., Park, S., Han, J.-W., Karamyan, V., Okun, E., Dheen, T., Hande, M. P., Vemuganti, R., Mallilankaraman, K., Lim, L. H. K., … Arumugam, T. V. (2022). Integrative epigenomic and transcriptomic analyses reveal metabolic switching by intermittent fasting in brain.

  • M. Lee, L. Mangnier, C. Padilla , D. P. Lee, W. Tan, Peter Y.Q., W. H. Zheng, L. Gan, C. K. Chen, Y. P. Lim, R. Wang, S. Bilodeau, A. Bureau, R. S. Y. Foo, C. Anene-Nzelu, 2022, CTCF mediates the Activity-by-contact derived cis-regulatory hubs.

  • Lee, D. P., Ray, W. J., Mei, T. P., Hoon, S., Scolnick, J., & Yeo, G. W. (2022). Antibody–Oligonucleotide Conjugation Using a SPAAC Copper-Free Method Compatible with 10× Genomics’ Single-Cell RNA-Seq.