Chloe Nguyen
Masters Student
Biology
Summary
Chloe is a recent graduate of UC San Diego now pursuing her Master's degree in Biology. Under the mentorship of Dr. Norah Al-Azzam, Chloe was previously a part of the CHMP7 project to understand how CHMP7 mislocalization contributes to amyotrophic lateral sclerosis (ALS) neuropathology. Now as an independent graduate student, Chloe is investigating the RNA-mediated mechanisms driving Huntington's Disease, specifically looking at the mutant HTT RNA interaction with RBPs and assessing any therapeutic potential of these complexes.
In her free time, Chloe enjoys discovering new eateries with friends, going to concerts, and reading.
Education
B.S., Human Biology, UC San Diego 2025
Contact
cbn003@ucsd.edu
Publications
Al-Azzam, N., To, J. H., Gautam, V., Street, L. A., Nguyen, C. B., Naritomi, J. T., Lam, D. C., Madrigal, A. A., Lee, B., Jin, W., Avina, A., Mizrahi, O., Mueller, J. R., Ford, W., Schiavon, C. R., Rebollo, E., Vu, A. Q., Blue, S. M., Madakamutil, Y. L., Manor, U., … Yeo, G. W. (2024). Inhibition of RNA splicing triggers CHMP7 nuclear entry, impacting TDP-43 function and leading to the onset of ALS cellular phenotypes. Neuron, 112(24), 4033–4047.e8. https://doi.org/10.1016/j.neuron.2024.10.007