Assael A. Madrigal

Staff Research Associate

 

 

Summary

Assa (ă-să) recieved his BS in Biochemistry at UCSD 2016, while doing research in Dr. Rao's lab studying exosomes as a biomarker source of kidney injury and PHusis Therapeutics looking at small molecule inhibitors targeting KRAS. He is part of the ENCODE team working on CLIP variations to sail the ocean of molecular biology through RNA-RBP interactions.

My interest is in using molecular tools to study interaction networks in evolution or activity dependent modifications. To this end I am seeking a deep foundation in CLIP and scRNA through experience.

 

Education

B.S., Biochemistry & Cell Biology, UC San Diego, 2016

A.S., Mathematics, Palomar College, 2013

 

Contact

aamadrig at ucsd.edu

Publications

  • Smargon AA, Madrigal AA, Yee BA, Dong KD, Mueller JR, Yeo GW. Crosstalk between CRISPR-Cas9 and the human transcriptome. Nat Commun. 2022 Mar 2

  • Wang SC, Davejan P, Hendargo KJ, Javadi-Razaz I, Chou A, Yee DC, Ghazi F, Lam KJK, Conn AM, Madrigal A, Medrano-Soto A, Saier MH Jr. Expansion of the Major Facilitator Superfamily (MFS) to include novel transporters as well as transmembrane-acting enzymes. Biochim Biophys Acta Biomembr. 2020 Sep 1;1862(9):183277

  • Brannan KW, Chaim IA, Marina RJ, Yee BA, Kofman ER, Lorenz DA, Jagannatha P, Dong KD, Madrigal AA, Underwood JG, Yeo GW. Robust single-cell discovery of RNA targets of RNA-binding proteins and ribosomes. Nat Methods. 2021 May;18(5):507-519.

  • Krach F, Batra R, Wheeler EC, Vu AQ, Wang R, Hutt K, Rabin SJ, Baughn MW, Libby RT, Diaz‑Garcia S, Stauffer J, Pirie E, Saberi S, Rodriguez M, Madrigal AA, Kohl Z, Winner B, Yeo GW, Ravits J. Transcriptome–pathology correlation identifies interplay between TDP‑43 and the expression of its kinase CK1E in sporadic ALS. Acta Neuropathologica, 2018.

  • RamachandraRao SP, Matthias MA, Kokoy-Mondrogon C, Aghania E, Park C, Kong C, Ishaya M, Madrigal A, Horng J, Khoshaba R, Bounkhoun A, Basilico F, De Palma A, Agresta AM, Awdishu L, Naviaux RK, Vinetz JM, Mauri P. Proteomic analysis of urine exosomes reveals renal tubule response to leptospiral colonization in experimentally infected rats. PLoS Negl Trop Dis. 2015 Apr 10;9(4):e0003718. doi: 10.1371/journal.pntd.0003718. PMID: 25860882

  • Satish P Ramachandrarao, Alyssa A Hamli, Linda Awdishu, Rachael Overcash, Marcela Zhou, James Proudfoot, Michelle Ishaya, Eamon Aghania, Assael Madrigal, Chanthel Kokoy-Mondragon, Kelly Kao, Roni Khoshaba, Anousone Bounkhoun, Majid Ghassemian, Maryam Tarsa and Robert K Naviaux. Proteomic Analyses of Urine Exosomes Reveal New Biomarkers of Diabetes in Pregnancy. Madridge Journal of Diabetes. 2016 Feb 1; 1(1): 11-22.